Preface: Jack Ma once predicted, "The next person who can surpass me will definitely appear in the health industry.

Main body:

In today's healthy environment, it's not an exaggeration to say that almost everyone knows about probiotics, right?

New opportunities brought by the epidemic

Since around 2020, the outbreak of COVID-19 has strengthened consumers' awareness of immune nutrition products, among which probiotic products have rapidly become "new favorites" due to their efficacy in improving intestinal health, immune health, etc. As one of the fastest growing sub sectors, the probiotics market has become a battleground for the nutrition and health industries.

Although many active metabolites have good functions, the production, transportation, and storage requirements of probiotic "active" metabolites are relatively high, which to some extent limits their large-scale production and application^〔1〕。 

In the field of microbiology research, the study of epigenetic elements is another important development direction in the research of probiotic metabolites. In fact, as early as 2020, one of the "Top Ten Hotspots in Probiotic Science Research" was probiotics and prebiotics/prebiotics. Epibiotics and probiotics have significant differences, referring to the metabolic components of probiotics after processing. By definition, Epibiotics are inactivated and do not have activity limitations compared to probiotics, but they can retain effective ingredients to exert their effects.

Postbiotics has opened the fourth generation of new dynasties after probiotics, prebiotics, and synbiotics. Postbiotics has achieved rapid development and its official definition and scope have been declared by the International Association of Probiotics and Probiotics Scientific Societies (ISAPP)Postbiotics refer to preparations of non living microorganisms or their components that are beneficial to health, including dead bacterial cells and their metabolites of probiotics. It emphasizes that postbiotics are not a single active substance, but a mixture of multiple beneficial active substances, leading China's postbiotics industry onto the correct track of healthy and benign development.

This is the industry innovation brought about by the emergence of raw materials. Now that we are in 2023, the big health market is still boiling like yesterday. So, what new ideas do we have when we talk about reincarnation.

Having diversified advantagespostbiotics

A large number of in vivo and in vitro experiments have confirmed the diversity of epigenetic functions, including antioxidant, anti-inflammatory, balancing gut microbiota, enhancing intestinal epithelial barrier function, enhancing immune regulation, and promoting metabolism. In addition to the aforementioned functions, compared to probiotics,后生元还具有多个优点：一是更稳定，具有更长的保质期和更好的环境耐受性；二是安全性更高，对一些特殊人群如新生儿、敏感人群同样适应。三是后生元也不受抗生素的干扰抑制，不存在传递耐药基因的风险；四是后生元中的活性物质更易于被肠道吸收，提高利用率；五是后生元具有更广泛的作用靶点，不仅限于肠道，还包括口腔、皮肤、泌尿生殖道或鼻咽等。因此，后生元应用范围非常广泛，可以用于食品、保健品、化妆品、饲料等多个行业中，具有广阔的市场应用前景^〔3〕。Postbiotics also have multiple advantages: firstly, they are more stable, have a longer shelf life, and better environmental tolerance; Secondly, it has higher safety and is also suitable for some special populations such as newborns and sensitive individuals. Thirdly, there is no risk of transmitting antibiotic resistance genes as the epigenetic elements are not affected or inhibited by antibiotics; Fourthly, the active substances in the epigenetics are more easily absorbed by the intestine, improving utilization efficiency; The fifth is that the epigenetic elements have a wider range of targets, not limited to the intestine, but also including the oral cavity, skin, urinary and reproductive tract, or nasopharynx. Therefore, the application scope of epigenetic elements is very wide and can be used in multiple industries such as food, health products, cosmetics, and feed, with broad market application prospects [3].

Therefore, the main advantages of Houshengyuan in various industries are high stability, high safety, and easy storage. These characteristics make it shine in the fields of functional food and beverage, nutritional health products, functional skincare, pet nutrition feed, auxiliary treatment of oral diseases, and biological preservation. Since epigenetic element can play its role without maintaining its activity, its downstream commercial applications are also relatively diversified. In daily life, we can see epigenetic element in the application of biscuits, bread, dairy products, soft sweets, capsules, facial mask and other products.

That's why we have seen a revolutionary change in probiotic health products in just a few years. The advantages brought by prebiotics are significant, and the market size of prebiotics has grown rapidly. At the same time, it has also accelerated the industrial layout of related research enterprises such as Yuanda Biotechnology.

The dividend of planning policies continues to boost the market worth billions, and it is ready to take off!

at with the continuous breakthroughs in scientific research technology and the support of relevant laws and policies at home and abroad, the performance and application advantages of Postbiotics have been unprecedentedly improved.

As a result, the emerging product line has sprung up like mushrooms in front of consumers, and the scale of the industry is still gradually increasing. For example, not long ago, as one of the leaders in China's emerging industries, Yuanda Biotechnology relied on functional epigenetic anti-corrosion materials have become popular at the International Prefabricated Vegetable Conference, receiving widespread attention and inquiries. The market potential and dividends are just around the corner.

This has also accelerated the layout of the big health industry chain, and the concept of using youth to benefit health is deeply rooted in the hearts of consumers.

From the perspective of consumer awareness, according to a survey conducted by Mintel, in 2019, the global internet users' attention to emerging products on social media has nearly doubled compared to the previous year. The search volume for "young elements" on search engines has increased more than tenfold between 2019 and 2021. It can be said very intuitively how much attention this field is receiving.

Source: Mintel

On the other hand, research on epigenetics continues to deepen, and studies related to epigenetics have surpassed triple digits from single digits in 2000 to 2022. Literature research on epigenetics has grown significantly in recent years, and now exceeds 200 articles.

From the perspective of the size of the emerging market, according to Euromonitor data, it is expected that the global emerging market will reach a scale of over 100 billion within 5 years.

It can be said that there is still a huge potential market for emerging products in consumer demand, but some problems are gradually emerging today,

For example, to analyze and identify the effector molecules that exert a specific effect on the secondary generation, and to elucidate their mechanism of action; The efficacy evaluation and safety of epigenetic elements still require extensive clinical trial verification; The lag in laws, regulations, and standards, as well as consumer attitudes, have to some extent limited the commercial development of emerging products.

While continuing in-depth research, promote integrated development

Although there are some limitations in the current research and application development of metamaterials, the potential for industrialization of metamaterials is still being explored, which requires time accumulation and research and development investment.

The convening of the first China Postbiotics Technology Conference in 2022 further promotes the integration of industry, academia, and research, promotes the transformation and high-quality development of research and industrialization achievements in Postbiotics, and gradually covers the fields of food, health products, cosmetics, feed, plant nutrition, etc., bringing unprecedented diversification and efficacy characteristics.

On February 21, 2023, the release of the first domestic group standard for probiotic products and probiotics has epoch-making significance for the high-quality development of China's probiotic and probiotics industry.

Postnatal elements are not as simplistic as the general public may seem, and the road to their development is long and arduous. Leading domestic enterprises that integrate scientific research and production, such as Yuanda Biotechnology, are also constantly deepening their cultivation,Yuanda Biotechnology not only has a specialized strain resource library for screening post biotics, but also has collected more than 3000 strains of strains. It has also mastered key preparation technologies for post biotics, including efficient enrichment techniques for effective factors, thereby promoting the integration and development of post biotics with multiple major health industries.

Postbiotics has brought better and safer probiotic functional solutions. With the advancement of scientific research and market standards, we believe that Postbiotics will better play its own value, open up more possibilities for the domestic market, and meet the growing health needs of consumers and the market.

So today we will talk about the emergence of probiotics. As an excellent health effect factor, it will lead the development of a new round of disruptive probiotic technology revolution. Perhaps it can also become a new foundation for other formulations in the future, paving a golden road for the future health industry through technological innovation. It can be a pioneer or a founder.

The industrialization development in the field of emerging elements has just begun, let's wait and see.

References:

【one】【two】* Lan Dongxue，Qu Qiannan，Peng Chuantao, Li Zhaojie《Research and application progress of probiotic active metabolitesHow to translate

【three】【four】* Qu Qiannan, Lan Dongxue, Peng Chuantao, Li Zhaojie《Research progress on the function and application of epigenetic elementsHow to translate