As the sky watches, it's getting hotter and hotter. In the season where fresh food and draft beer are rampant, the digestive department welcomes batches of patients who attempt to beat the heat with cold and stimulating food, but fail to cause diarrhea and stomach discomfort.

Every year, during the high incidence of stomach diseases in summer, the topic of Helicobacter pylori is again popular in once again. If you find yourself infected with Helicobacter pylori (Hp) during a physical examination, don't panic or scream. The editor can only congratulate you. At this point, the dinner party is just a floating cloud and will never return on the road of social anxiety.

This is not an exaggeration~There's nothing we can do, but Helicobacter pylori is a Class I carcinogen that can't even kill stomach acid.

Talking about the raging Helicobacter pylori that turns pale and pale

Helicobacter pylori (Hp), also known as the "ghost" in the stomach, is a microaerophilic gram-negative bacterium that is spiral shaped and can colonize the human stomach for a long time, causing chronic inflammation. It can be transmitted through oral and fecal transmission and has familial aggregation.

It has extremely strong combat power! The harm is also extremely strong! Extremely strong dissemination power!

In recent years, a series of studies have shown that Hp infection significantly increases the risk of gastric cancer, and multiple mechanisms underlying its induction of gastric cancer have been identified.

• As early as 1994, Helicobacter pylori was classified as a Group I human carcinogen by the International Agency for Research on Cancer (IARC), and its carcinogenic risk was confirmed to be accurate.

• In 2021, the medical journal The Lancet reported that China accounts for about half of the world's confirmed cases of gastric cancer, with approximately 340000 new cases of gastric cancer related to Helicobacter pylori infection

• In 2021, the US Department of Health and Human Services released the 15th edition of the Carcinogen Report, which added 8 new carcinogens. Chronic infection with Helicobacter pylori was listed as a clear carcinogen.

• The World Health Report shows that nearly half of stomach cancer is related to Helicobacter pylori.

• According to the white paper on the prevention and control of Helicobacter pylori infection in China, the infection rate among the population is 40% to 90%, with an average of 59%, about 800 million people. Among them, the infection rate among children is about 40%.

The study also found that Helicobacter pylori infection increases the risk of gastric cancer by 2.7-12 times. Such a high-risk pathogenic bacterium, actually discovered only over 40 years ago, does not affect its significance in any way. It can be called explosive news in the medical field. Do you know who discovered it?

Medical sensation: discovery of Helicobacter pylori

According to the British journal Nature, Helicobacter pylori (Hp), a bacterium that causes stomach ulcers, has been present in the human digestive system since modern humans left Africa and began migrating 60000 years ago.

But initially, the conclusion that "there are no bacteria in the stomach" dominated the field of digestion for nearly a hundred years, to the point where when people sought medical attention for stomach discomfort, doctors would solemnly say, "Damn it, you've been under a lot of pressure lately. Go back and drink more hot water.

Until 1981, a ruthless person appeared. Barry J. Marshall, who was still a graduate student at the time, discovered Helicobacter pylori and, in order to prove its role in diseases such as gastritis and gastric ulcers, he did not hesitate to "test himself" by simply gulping down a cup of the bacteria's culture medium.

As expected, five days after drinking it, Marshall "fulfilled his wish" and developed acute gastritis, accompanied by symptoms of nausea, vomiting, and stomach pain. After biopsy, Helicobacter pylori in the stomach was also isolated and cultured, confirming the existence of this culprit causing gastric ulcers.

At this point, people gradually realized the toxicity of Helicobacter pylori and its associated diseases, and research on Helicobacter pylori has also made rapid progress. The discovery of Helicobacter pylori became an important milestone in the medical history of the 20th century, and Warren and Marshall were awarded the Nobel Prize in Physiology or Medicine for their revolutionary discoveries.

The Long and Obstacle resistant Road: Antibiotics vs. Probiotics

To this day, the academic community has been constantly learning about research and eradication plans for Helicobacter pylori every year.

The Expert Consensus on Prevention, Control, and Management of Helicobacter pylori Infection in Chinese Residential Families (2021) states that eradication treatment should be considered for all adult Helicobacter pylori infected individuals in their families.

Physical methods, such as washing hands promptly, disinfecting utensils, and eating separately, can only serve as a basic prevention/defense strategy, but under the powerful attack of "contracting Helicobacter pylori, one infects two, two infects a nest", this entry-level method is also essential.

In terms of research, the current methods for treating Helicobacter pylori infection are relatively mature. The first-line treatment plan for eradicating Helicobacter pylori recommended by authoritative guidelines at home and abroad is triple therapy (PPI+2 antibiotics) and 14 day course quadruple therapy (bismuth+PPI+2 antibiotics). Smash, this is simply a 'big bomb' of antibiotics.

Reasonable anti Helicobacter pylori regimen/Dingxiangyuan digestion time

Flipping through a certain book, most patients share with tears and blood that after eating so many bitter medicines, it feels like their stomach is churning and rushing.

Check in quadruple sterilization/Xiaohongshu @ GGGuo Liu

Moreover, these solutions based on chemically synthesized drugs can lead to various side effects when taken for a long time, including antibiotic resistance, a significant decrease in eradication effectiveness, and other problems such as liver function damage while killing bacteria.

In addition to the competition plans of pharmaceutical representatives, there have also been varying degrees of "intelligence taxes" in the market, which is truly puzzling.

Toothpaste against Helicobacter pylori? mouth wash? Mouth spray? Ointment? dishwasher??

Get it figured out, buddy. Helicobacter pylori is mainly stored in the stomach, and even strong acids are difficult to kill it, let alone a toothpaste! Did toothpaste contain antibiotics? Do you still want to swallow it? (Shocking+10086)

Moreover, the official platform of the State Food and Drug Administration in 2022 clearly stated in the article "Toothpaste cannot treat diseases" that toothpaste's claim of "anti Helicobacter pylori" lacks scientific basis.

There are also many mystical formulas that claim to be ancestral: honey? Toothpaste? Garlic? Onion? High Baijiu? These not only have no anti dark effect, but may also cause another critical blow to the gastric mucosa.

If that's the case, what other methods are there to prevent/treat Helicobacter pylori?

This is a problem as well as a challenge。

Defeat Magic with Magic: Treat Fungi with Fungi

Research has shown that Helicobacter pylori can secrete urease, break down urea in the stomach, produce ammonia, neutralize gastric acid, and liquefy the mucin of the gastric epithelial cell layer in a neutral environment. Helicobacter pylori uses its spiral structure to penetrate the mucus layer and colonize the epithelial cells. Then harmful substances such as vacuolating toxins and endotoxins are produced, causing chronic gastritis and gradually developing into gastric ulcers and even gastric cancer.

The concept of using bacteria to treat bacteria was proposed by great scientists as early as 1997 on the road of resisting evil spirits. Natural selection, survival of the fittest, and the competition between these bacteria in nature also exist, so using magic to defeat magic is one of the most desirable ways.

• Multiple clinical studies have reported the effect of probiotics alone or in combination with drugs on eradicating Helicobacter pylori. Consensus guidelines both domestically and internationally have also discussed the positive impact of probiotics in eradicating Helicobacter pylori.

• The White Paper on the Development Trends of Global Probiotics Industry University Research in 2021 shows that adjuvant therapy for Helicobacter pylori infection is one of the main aspects of probiotic research.

As the world's most populous country, China's high infection rate implies a huge market space for treatment and screening.

Especially when news related to Helicobacter pylori ranks among the top of the hot search list, not only are domestic large companies rapidly laying out probiotics for antibacterial purposes, but food companies are also entering the market, which has also sparked the popularity of "Helicobacter pylori" concept stocks in the capital market.

• Yueyang Xingchang closed up the daily limit, as the company had announced the development of an anti You vaccine several years ago;

• SJTU Angli hit the daily limit up, with the company claiming to hold anti You probiotic products;

• Koto Biotech has seen a significant increase, as the company claims to have probiotic drinks targeting Helicobacter pylori;

• Shanshui Technology has seen significant growth, with the company stating that 2,6-dichloropyridine can be used as a Helicobacter pylori inhibitor and other drugs. [1]

• …………

From the perspective of the ultimate efficacy of anti Helicobacter pylori, although current in vitro studies, animal experiments, and clinical observations have shown that probiotics have certain effectiveness in combating Helicobacter pylori, more solid evidence-based accumulation and market supervision are still needed for the treatment/prevention of Helicobacter pylori infection. [2]

Another point worth noting is that probiotics are prone to high temperature inactivation, and their safety and stability are difficult to control. After passing through gastric acid choline, there are not many bacteria that can be effective. Even Nobel laureate Barry Marshall, who was the first to drink Helicobacter pylori, once said that probiotics are not much different from food in the stomach and are almost digested, making it difficult to survive in the stomach.  

Although live bacteria are good, maintaining their activity is difficult

Probiotics are live bacteria with requirements for maintaining activity and limited types of food that can be added;

Probiotics work by directly or indirectly affecting the growth of gut microbiota, so whether they can continue to bring benefits also depends on whether other gut microbiota can successfully colonize in the intestine [3], and the suitable strains for people's intestines vary [4].

With more and more scientists conducting research, the targeted anti dark effects of epigenetic elements have also been discovered.

New discovery in the field of anti-aging: targeted protection of the "stomach" by epigenetic elements

As a cutting-edge field of microecology research that has received much attention in recent years, the effective mechanisms of action between post biotics and gut microbiota, health benefits, gut health, and immune health have been extensively confirmed by international studies.

Experts have expressed that the emergence of prebiotics not only brings better and safer probiotic functional solutions, but also represents a leapfrog development in food innovation.

Postbiotics refer to preparations of non living microorganisms and/or other components that are beneficial to the health of the host. Due to its characteristics such as being lifeless, it has enormous potential for application.

In this regard, enterprises with professional strength in the field of big health have begun to lay out targeted anti-aging systems for emerging elements, and scientific evidence will become the technical key to product creation. Currently, the focus is on Postbiocare, the first genetically modified Postbiocare developed independently by Yuanda Biotechnology, which targets and effectively protects the stomach ®。

Any successful micro ecological product cannot do without sufficient scientific research. The latest study by Yuanda Biology found that only by taking Postbiocare ®， It can significantly reduce Helicobacter pylori in the intestine.

This study indicates that Postbiocare, a type of epigenetic element ® To ensure the effective ingredients reach the gastrointestinal tract to a greater extent, they can recognize the surface protein structure of Helicobacter pylori and bind with it to form polymers. Then the copolymer is excreted from the body through the gastrointestinal tract, thereby reducing the number of Helicobacter pylori in the stomach and effectively targeting the "stomach".

Researchers, based on scientific evidence, first discovered from experimental results on the inhibition of Helicobacter pylori that Postbiocare is an epigenetic molecule ® It can significantly inhibit the growth of Helicobacter pylori, and the significant antibacterial effect is about twice that of commercially available antibacterial products!

Efficient inhibition of Helicobacter pylori

Another experiment on the adsorption of Helicobacter pylori found that through quartz crystal microbalance (QCM), it was demonstrated that Postbiocare, a derivative of Helicobacter pylori ® It can quickly identify and bind to Helicobacter pylori, inhibit the proliferation and growth of Helicobacter pylori, cover the surface binding sites, and cannot adhere to the gastric mucosa, effectively alleviating gastritis and gastric ulcers caused by Helicobacter pylori, improving symptoms such as superficial gastritis and gastroesophageal reflux.

Targeted adsorption of Helicobacter pylori

Unlike typical bacterial cells, Postbiocare ® The inherent inactivation has more advantages in targeted anti UV polymerization. This feature not only reduces the difficulty of transportation and storage, but also suggests that when used in combination with antibiotics, the epigenetic element Postbiocare ® It will not lose its ability to bind to Helicobacter pylori due to the action of antibiotics, increasing its feasibility for combination use with antibiotics.

One stone stirred up a thousand waves, instantly sparking heated discussions. Facing the era of rampant Helicobacter pylori, Postbiocare ® The safety, drug resistance, and antimicrobial efficacy have been clinically proven, and it is expected to trigger a new direction in the capital market. Of course, we also look forward to more information about its efficacy, which can deliver a fatal blow to Helicobacter pylori. This is also a highly exploratory event in the field of afterlife.

[Written at the end]

Nowadays, hidden killers such as Helicobacter pylori and even gastric cancer are gradually attacking young people. If you are really infected with Helicobacter pylori, you still need to use physical methods (daily habits) and magic attacks (prevention/screening/treatment), which will greatly reduce the chance of contracting Helicobacter pylori.

Secondly, the country is vigorously implementing the Healthy China strategy, and the related scientific research progress is impressive. So, in the face of resisting the dark, we still need to believe in science in order to have no worries about the dark~

[1] What happened when the concept stocks of "anti harmful probiotics" in China hit the daily limit up? Is it really useful? Intestinal industry

[3] Sanders M E. Impact of Probiotics on Colonizing Microbiota of the Gut. Journal of Clinical Gastroenterology, 2011, 45: S115–S119[2021-04-25].  https://doi.org/10.1097/mcg.0b013e318227414a.

[4] Jessica Brown.What we do and don’t know about gut health[J/OL]. (2019-01-23)[2021-04-12]. https://www.bbc.com/future/article/20190121-what-we-do-and-dont-know-about-gut-health.